A giant in intensive care presents a gift to young Japanese researchers—Prof Bellomo [JSICM 50th Anniversary Oceania Week [Redistribution]
2025/5/14
In memory of Professor Rinaldo Bellomo, we are rebroadcasting an interview recorded in July 2023
＝
Drawing on the 30-year history of ANZICS-CTG, which has been dedicated to exploring evidence-based medicine (EBM) and improving patient’s outcomes, this presentation highlights the importance of questioning what people believe and collaborating as a team to verify findings
*Prof Rinaldo Bellomo*
Austin Health (VIC, Australia) ICU Research Director, Intensive Care Specialist
Co-Director, ANZIC-RC, Monash University School of Public Health, Australia and New Zealand Intensive Care Research Centre
Founding Director, ANZICS-CTG
Twitter (X) @BellomoRinaldo
*ANZICS-CTG*
https://www.anzics.com.au/clinical-trials-group/
*Dopamine trial*
Bellomo R et al. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group _ Lancet. _ 2000 Dec;356(9248):2139-43. doi: 10.1016/s0140-6736(00)03495-4.
https://pubmed.ncbi.nlm.nih.gov/11191541/
*The George Institute for Global Health*
https://www.georgeinstitute.org/
*SAFE trial*
Finfer S et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit _ N Engl J Med. _ 2004 May 27;350(22):2247-56. doi: 10.1056/NEJMoa040232.
https://pubmed.ncbi.nlm.nih.gov/15163774/
SAFE Study Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group; Australian Red Cross Blood Service; George Institute for International Health. Saline or albumin for fluid resuscitation in patients with traumatic brain injury _ N Engl J Med. _ 2007 Aug 30;357(9):874-84. doi: 10.1056/NEJMoa067514.
https://pubmed.ncbi.nlm.nih.gov/17761591/
*NICE-SUGAR trial*
NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients _ N Engl J Med. _ 2009 Mar 26;360(13):1283-97. doi: 10.1056/NEJMoa0810625.
https://pubmed.ncbi.nlm.nih.gov/19318384/
*RENAL trial*
RENAL Replacement Therapy Study Investigators. Intensity of continuous renal-replacement therapy in critically ill patients _ N Engl J Med. _ 2009 Oct 22;361(17):1627-38. doi: 10.1056/NEJMoa0902413.
https://pubmed.ncbi.nlm.nih.gov/19846848/
*ANZIC-RC*
A research organisation jointly funded by the NHMRC (an organisation that formulates medical and public health policies and provides funding for related research on behalf of the Australian government) and Monash University, and a division of the Monash University School of Public Health.
*This is a different organisation from ANZICS.
https://www.monash.edu/medicine/sphpm/anzicrc
*【TAME program】*
Bellomo R et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest _ Crit Care. _ 2011;15(2):R90. doi: 10.1186/cc10090.
https://pubmed.ncbi.nlm.nih.gov/21385416/
Schneider A et al. Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest _ Resuscitation. _ 2013 Jul;84(7):927-34. doi: 10.1186/cc10090.
https://pubmed.ncbi.nlm.nih.gov/23454258/
Eastwood GM et al. Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial) _ Resuscitation. _ 2016 Jul;104:83-90. doi: 10.1016/j.resuscitation.2016.03.023
https://pubmed.ncbi.nlm.nih.gov/21385416/
Eastwood GM et al. Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest _ N Engl J Med. _ 2023 Jul 6;389(1):45-57. doi: 10.1056/NEJMoa2214552.
https://pubmed.ncbi.nlm.nih.gov/37318140/
*【Bicarbonate (SODa-BIC) program】*
Jude B et al. Sodium bicarbonate in 5% dextrose: can clinicians tell the difference? _ Crit Care Resusc. _ 2020 Mar;22(1):80-82.
https://pubmed.ncbi.nlm.nih.gov/32102646/
Naorungroj T et al. Stability of bicarbonate in normal saline: a technical report _ Crit Care Resusc. _ 2020 Mar;22(1):83-85.
https://pubmed.ncbi.nlm.nih.gov/32102647/
Mochizuki K et al. Acidemia subtypes in critically ill patients: An international cohort study _ J Crit Care _. 2021 Aug;64:10-17. doi: 10.1016/j.jcrc.2021.02.006.
https://pubmed.ncbi.nlm.nih.gov/33725556/
Fujii T et al. Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study _ Crit Care. _ 2021 Feb 2;25(1):45. doi: 10.1186/s13054-020-03431-2.
https://pubmed.ncbi.nlm.nih.gov/33531020/
Serpa Neto A et al. Sodium bicarbonate therapy for metabolic acidosis in critically ill patients: a survey of Australian and New Zealand intensive care clinicians _ Crit Care Resusc. _ 2020 Sep;22(3):275-280.
https://pubmed.ncbi.nlm.nih.gov/32900336/
Fujii T et al. Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review _ J Crit Care. _ 2019 Jun;51:184-191. doi: 10.1016/j.jcrc.2019.02.027.
https://pubmed.ncbi.nlm.nih.gov/30852347/
*MERCY trial*
Monti G et al. Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial. _ JAMA _2023 Jul 11;330(2):141-151. doi: 10.1001/jama.2023.10598.
https://pubmed.ncbi.nlm.nih.gov/37326473/
＝
Drawing on the 30-year history of ANZICS-CTG, which has been dedicated to exploring evidence-based medicine (EBM) and improving patient’s outcomes, this presentation highlights the importance of questioning what people believe and collaborating as a team to verify findings
|
00:00 Opening 01:39 The origins of EBM and the 30-year history of ANZICS-CTG 14:14 Professor Bellomo's Motivation and Mentors 17:40 Managing Time and Energy 21:27 Research Environments in Japan and Australia 29:38 Communicating via social media 33:37 Considering clinical research topics in clinical practice 37:06 Changes AI will bring to clinical research 42:52 Expectations for future critical care physicians and education 46:58 Closing remarks |
*Prof Rinaldo Bellomo*
Austin Health (VIC, Australia) ICU Research Director, Intensive Care Specialist
Co-Director, ANZIC-RC, Monash University School of Public Health, Australia and New Zealand Intensive Care Research Centre
Founding Director, ANZICS-CTG
Twitter (X) @BellomoRinaldo
*ANZICS-CTG*
https://www.anzics.com.au/clinical-trials-group/
*Dopamine trial*
Bellomo R et al. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group _ Lancet. _ 2000 Dec;356(9248):2139-43. doi: 10.1016/s0140-6736(00)03495-4.
https://pubmed.ncbi.nlm.nih.gov/11191541/
*The George Institute for Global Health*
https://www.georgeinstitute.org/
*SAFE trial*
Finfer S et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit _ N Engl J Med. _ 2004 May 27;350(22):2247-56. doi: 10.1056/NEJMoa040232.
https://pubmed.ncbi.nlm.nih.gov/15163774/
SAFE Study Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group; Australian Red Cross Blood Service; George Institute for International Health. Saline or albumin for fluid resuscitation in patients with traumatic brain injury _ N Engl J Med. _ 2007 Aug 30;357(9):874-84. doi: 10.1056/NEJMoa067514.
https://pubmed.ncbi.nlm.nih.gov/17761591/
*NICE-SUGAR trial*
NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients _ N Engl J Med. _ 2009 Mar 26;360(13):1283-97. doi: 10.1056/NEJMoa0810625.
https://pubmed.ncbi.nlm.nih.gov/19318384/
*RENAL trial*
RENAL Replacement Therapy Study Investigators. Intensity of continuous renal-replacement therapy in critically ill patients _ N Engl J Med. _ 2009 Oct 22;361(17):1627-38. doi: 10.1056/NEJMoa0902413.
https://pubmed.ncbi.nlm.nih.gov/19846848/
*ANZIC-RC*
A research organisation jointly funded by the NHMRC (an organisation that formulates medical and public health policies and provides funding for related research on behalf of the Australian government) and Monash University, and a division of the Monash University School of Public Health.
*This is a different organisation from ANZICS.
https://www.monash.edu/medicine/sphpm/anzicrc
*【TAME program】*
Bellomo R et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest _ Crit Care. _ 2011;15(2):R90. doi: 10.1186/cc10090.
https://pubmed.ncbi.nlm.nih.gov/21385416/
Schneider A et al. Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest _ Resuscitation. _ 2013 Jul;84(7):927-34. doi: 10.1186/cc10090.
https://pubmed.ncbi.nlm.nih.gov/23454258/
Eastwood GM et al. Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial) _ Resuscitation. _ 2016 Jul;104:83-90. doi: 10.1016/j.resuscitation.2016.03.023
https://pubmed.ncbi.nlm.nih.gov/21385416/
Eastwood GM et al. Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest _ N Engl J Med. _ 2023 Jul 6;389(1):45-57. doi: 10.1056/NEJMoa2214552.
https://pubmed.ncbi.nlm.nih.gov/37318140/
*【Bicarbonate (SODa-BIC) program】*
Jude B et al. Sodium bicarbonate in 5% dextrose: can clinicians tell the difference? _ Crit Care Resusc. _ 2020 Mar;22(1):80-82.
https://pubmed.ncbi.nlm.nih.gov/32102646/
Naorungroj T et al. Stability of bicarbonate in normal saline: a technical report _ Crit Care Resusc. _ 2020 Mar;22(1):83-85.
https://pubmed.ncbi.nlm.nih.gov/32102647/
Mochizuki K et al. Acidemia subtypes in critically ill patients: An international cohort study _ J Crit Care _. 2021 Aug;64:10-17. doi: 10.1016/j.jcrc.2021.02.006.
https://pubmed.ncbi.nlm.nih.gov/33725556/
Fujii T et al. Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study _ Crit Care. _ 2021 Feb 2;25(1):45. doi: 10.1186/s13054-020-03431-2.
https://pubmed.ncbi.nlm.nih.gov/33531020/
Serpa Neto A et al. Sodium bicarbonate therapy for metabolic acidosis in critically ill patients: a survey of Australian and New Zealand intensive care clinicians _ Crit Care Resusc. _ 2020 Sep;22(3):275-280.
https://pubmed.ncbi.nlm.nih.gov/32900336/
Fujii T et al. Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review _ J Crit Care. _ 2019 Jun;51:184-191. doi: 10.1016/j.jcrc.2019.02.027.
https://pubmed.ncbi.nlm.nih.gov/30852347/
*MERCY trial*
Monti G et al. Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial. _ JAMA _2023 Jul 11;330(2):141-151. doi: 10.1001/jama.2023.10598.
https://pubmed.ncbi.nlm.nih.gov/37326473/
